Fantasy Football Profile - Isaac Guerendo

Fantasy Football Player Profile

Isaac Guerendo
San Francisco 49ers

2025 Projected Value: $0
2025 Actual Value: $0 Difference: $0
Based on 10-team N-only league

Player News

Date	News
8/30/25	Is Isaac Guerendo Playing Week 1? Latest Injury Update for the San Francisco 49ers RB. Could Isaac Guerendo's shoulder injury threaten his Week 1 availability? Here's how fantasy managers should approach the 49ers' sophomore RB. Source: https://www.profootballnetwork.com/fantasy-footbal...
8/29/25	Should I Draft Isaac Guerendo? Fantasy Outlook for the 49ers RB in 2025. Isaac Guerendo proved he can be a fantasy RB1 when given volume. How much should fantasy managers be willing to invest in Christian McCaffrey's backup? Source: https://www.profootballnetwork.com/fantasy-footbal...
8/28/25	Is Isaac Guerendo Playing Week 1? Latest Injury Update for the San Francisco 49ers RB. Does Isaac Guerendo's shoulder injury threaten his Week 1 status with the 49ers? Here's how fantasy managers should approach the sophomore RB. Source: https://www.profootballnetwork.com/fantasy-footbal...
8/23/25	Is Isaac Guerendo Playing Week 1? Latest Injury Update for the San Francisco 49ers RB. Isaac Guerendo's shoulder injury threatens his Week 1 status with the 49ers. Fantasy managers should consider him as a reduced-cost handcuff to McCaffrey. Source: https://www.profootballnetwork.com/fantasy-footbal...
8/19/25	49ers RB Isaac Guerendo, CB Renardo Green stand out in return to practice. Isaac Guerendo and Renardo Green stood out during San Francisco 49ers practice Tuesday as they returned from their respective injuries. Source: https://sports.yahoo.com/article/49ers-rb-isaac-gu...
8/16/25	Isaac Guerendo Fantasy Profile: Is the 49ers RB a Priority Handcuff?. Isaac Guerendo proved he can be a fantasy RB1 when given volume. How much should fantasy managers be willing to invest in Christian McCaffrey's backup? Source: https://www.profootballnetwork.com/fantasy-footbal...
8/14/25	49ers injury report: Roll call on this camp's injuries before facing Raiders. Isaac Guerendo: Injured his right shoulder on kick-return duties Aug. 2 and is expected out through the preseason. Jordan James: Rookie recently had surgery on his right hand to fix a fractured finger, following a knee issue that sidelined him four practices. Brandon Aiyuk: Sounds like he will remain on the Physically Unable To Perform list into the regular season and return for a Week 6 visit to Tampa Bay on Oct. 12. Jordan Watkins: Sustained a high ankle sprain in the preseason opener and might return in time for the Sept. 7 season opener. Source: https://www.mercurynews.com/2025/08/14/49ers-injur...
8/09/25	Isaac Guerendo Fantasy Profile: 49ers RB Is a Priority Handcuff. Isaac Guerendo proved he can be a fantasy RB1 when given volume. How much should fantasy managers be willing to invest in Christian McCaffrey's backup? Source: https://www.profootballnetwork.com/fantasy-footbal...
8/05/25	49ers Must Start Viewing This RB as an Injury-Prone Player. Injuries have been running rampant on the San Francisco 49ers since training camp began. On Monday, Kyle Shanahan announced that Isaac Guerendo will be out for a few weeks due to a shoulder injury. If the timeline he is out for holds up, Guerendo will miss all three of the preseason games. The 49ers must start viewing Guerendo as injury-prone moving forward. Source: https://www.si.com/nfl/49ers/news/49ers-must-start...
8/04/25	Isaac Guerendo out for a while. RB expected to miss a few weeks with shoulder issue 49ers RB Isaac Guerendo is expected to miss “a few weeks” with a shoulder injury, per Kyle Shanahan. (ESPN - Adam Schefter) FF Today's Take: Guerendo is no stranger to injuries. although hamstring issues have usually been his downfall. "A few weeks" is a vague timeline, but we can probably assume this injury will force him to miss every preseason game. While this injury may free up Christian McCaffrey to handle more of the early-season workload than most were expecting, it could also give rookie Jordan James a chance to make his case to be the No. 2 in San Francisco. James' preseason will be one to monitor as a result of this news. Source: https://www.fftoday.com/news/index.php?Item=16505...
5/04/25	Will the 49ers Trade Running Back Isaac Guerendo this Offseason?. Just a year ago, the 49ers traded up to take Isaac Guerendo in Round 4. "The San Francisco 49ers can never resist an enticing mid-round running back prospect," writes Pro Football Network's Sterling Xie. The Niners drafted bruising Oregon back Jordan James in the fifth round, a solid value for a player some felt could go on Day 2. Kiner was ranked no. 174 overall by CBS sports, meaning they expected Kiner to get picked in Round 5. Source: https://www.si.com/nfl/49ers/news/will-49ers-trade...
3/16/25	Will 49ers Draft Arizona State RB Cam Skattebo on Day 2 of NFL Draft?. Suddenly, the 49ers need a running back. Now they have Isaac Guerendo who carried the ball 84 times last season, and Christian McCaffrey who carried it 50 times. Both McCaffrey and Guerendo have extensive injury histories. Which means the 49ers almost certainly will spend an early draft pick on a running back who can carry a heavy workload if necessary, preferably one who's a good receiver like McCaffrey and Guerendo. Source: https://www.si.com/nfl/49ers/news/will-49ers-draft...
1/06/25	Standout 49ers rookie delivers positive update after scary Week 18 injury. The San Francisco 49ers watched one more injury scare in a season filled with those moments. Running back Isaac Guerendo left on a medical cart during their Week 18 game. Guerendo, however, shared a positive update one day after sustaining a frightening knee injury against the Arizona Cardinals. “ACL is good, thank you God,” Guerendo shared on his X account Monday. “I'll be back better than ever faithful!” Guerendo settled for only two carries for five yards in the road loss to the Cardinals. He watched the 49ers end a disappointing 2024 with a 47-24 Cardinals rout. The 23-point romp capped a 6-11 campaign for the defending NFC champions. Now, Guerendo can join the 49ers and head coach Kyle Shanahan Source: https://clutchpoints.com/49ers-news-standout-rooki...
1/05/25	Isaac Guerendo Injury Update: Latest on 49ers RB After Exiting Game vs. Cardinals in Week 18. Isaac Guerendo's rookie season came to an early end in Week 18. What's the latest on the 49ers' running back? Source: https://www.profootballnetwork.com/isaac-guerendo-...
12/29/24	49ers RB Guerendo 'good to go' against Lions. San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the Lions. Source: https://www.espn.com/nfl/story/_/id/43197403/49ers...
12/29/24	49ers RB Guerendo 'good to go' against Lions. San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the Lions. Source: https://www.espn.com/nfl/story/_/id/43197403/49ers...
12/28/24	Isaac Guerendo expected to play Monday night. 49ers RB Isaac Guerendo, who has been limited in practice this week due to hamstring and foot injuries, is expected to play Monday night against the Lions, per source. (Adam Schefter on X) FF Today's Take: Patrick Taylor (8-24-0, 1-1-0) turned in a dud last week against the Dolphins with Guerendo on the sidelines. Expect Guerendo to be back in the lead back role against the Lions on Monday night. He'll be a mid-range RB2 value for Week 17. The Lions have been stingy against RBs, giving up the 4th fewest fantasy points to the position. Source: https://www.fftoday.com/news/index.php?Item=16402...
12/26/24	Isaac Guerendo finally gives 49ers positive injury update. The San Francisco 49ers are making a final push to close out a lost season on a strong note. Injuries have decimated the reigning NFC champs. Isaac Guerendo, however, provided a promising update. The alternate running back appears to be on his way back , per 49ers reporter Nick Wagoner of ESPN Thursday. Guerendo became a limited participant in practice. Safety Ji'Ayir Brown (ankle) also joined the RB on the limited list. Guerendo has been dealing with a foot/hamstring ailment. He hasn't seen action since the Dec. 12 meeting against the Los Angeles Rams. Guerendo carried the football 16 times but netted only 57 yards in that 12-6 loss to their NFC West rival. Guerendo has handled 73 carries for Source: https://clutchpoints.com/49ers-news-isaac-guerendo...
12/23/24	Kyle Shanahan optimistic about breakout RB's return in Week 17 vs. Lions. The injury updates from San Francisco 49ers head coach Kyle Shanahan on Monday weren't all bad. Shanahan in a conference call the day after his team was eliminated from the postseason told reporters rookie running back Isaac Guerendo is trending toward a return in Week… Source: https://sports.yahoo.com/kyle-shanahan-optimistic-...
12/20/24	Williams, Guerendo out for 49ers-Dolphins; Greenlaw questionable. Trent Williams and Isaac Guerendo are ruled out, while Dre Greenlaw remains questionable for the San Francisco 49ers matchup with the Miami Dolphins on Sunday. Source: https://sports.yahoo.com/williams-guerendo-49ers-d...

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